水热法制备光热治疗剂纳米WO3-x的组织结构与光热效应

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摘要采用水热法制备表面活性剂聚甲基丙烯酸-季戊四醇四-3-巯基丙酸酯(PTMP-PMAA)修饰的具有光热效应的纳米WO_3-_x粉末,通过X射线衍射(XRD)分析、透射电镜(TEM)观察、X射线光电子能谱(XPS)分析、傅里叶变换红外光谱(FT-IR)分析以及紫外-可见吸收光谱(UV-Vis 谱)分析及光热性能测试等,研究所得纳米粉体材料的结构及其在不同浓度与pH值下的光热性能。结果表明,水热法制备的WO_3-_x粉末为球形的非整比结构的W₁₇O₄₇,粒径小于10 nm。随WO_3-_x的pH值降低或质量浓度降低,粉末的紫外吸光度增加,光热效应提高。pH值为6.4、质量浓度为800 μg/mL的WO_3-_x经光热转换后,可实现在5 min内约19 ℃的温度上升。考虑到人体体温为37 ℃,肿瘤部位的pH值为6.0~6.5之间,此质量浓度下纳米WO_3-_x粉末可用于光热治疗并实现对肿瘤细胞的杀伤效果。

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	胡伟
	黄智

关键词 ：水热法, WO_3-_x, pH值, 浓度, 光热效应, 紫外吸收

Abstract：PTMP-PMAA modified Nano-WO_3-_x powder was obtained by hydrothermal method. The effects of pH value and concentration on photothermal properties of the nano-WO_3-_x powder materials were studied by X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), UV-vis spectroscopy and photothermal property testing. The results show that the powders prepared by hydrothermal method are spherical nonintegral structure W₁₇O₄₈ with a particle size of less than 10 nm. The UV absorbance of the WO_3-_x material increases and the photothermal effect increases with decreasing the pH value or concentration of WO_3-_x. When pH 6.4 and mass concentration is 800 μg/mL, the temperature of WO_3-_x can rise nearly 19 ℃ in 5 minutes after photothermal conversion. Considering that the body temperature is 37 ℃ and the pH value of tumor site is between 6.0 and 6.5, nano-WO_3-_x powders at this concentration can be used in photothermal therapy and achieve the killing effect on tumor cells.

Key words： hydrothermal method WO_3-_x pH value concentration photothermal effect ultraviolet absorption

收稿日期: 2018-05-14 出版日期: 2019-07-12

ZTFLH:

TB31

基金资助:国家自然科学基金资助项目(81641085,81301536); 湖南省自然科学基金资助项目(11JJ1008)

通讯作者: 黄智,副教授,博士。电话：13875987521;E-mail: biomaterials@csu.edu.cn

引用本文:

胡伟, 黄智. 水热法制备光热治疗剂纳米WO_3-_x的组织结构与光热效应[J]. 粉末冶金材料科学与工程, 2019, 24(1): 37-44.
HU Wei, HUANG Zhi. Microstructure and photothermal effect of photothermal agent nanocrystalline WO_3-_x prepared by hydrothermal method. Materials Science and Engineering of Powder Metallurgy, 2019, 24(1): 37-44.

链接本文:

http://pmbjb.csu.edu.cn/CN/ 或 http://pmbjb.csu.edu.cn/CN/Y2019/V24/I1/37

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