1. State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China; 2. Xiangya Hospital, Central South University, Changsha 410083, China; 3. College of Biology, Hunan University, Changsha 410083, China
Abstract In order to meet the clinical requirements for corrosion resistance and osteogenesis of magnesium-based metal implants, the dense and uniform Mg-Fe-layered double hydroxide (Fe-LDH) coatings were prepared on the AZ91D Mg alloy matrix by hydrothermal method and the Fe-LDH/AZ91D samples were obtained. Electrochemical and hydrogen evolution experiments were performed to explore the effects of coatings on corrosion resistance and its in-vitro performance. Combining CCK-8 and in-vitro mineralization experiments, the biocompatibility and osteogenic properties of Fe-LDH/AZ91D were studied. The results show that the existence of the Fe-LDH coating establishes a barrier between AZ91D and the corrosive liquid and improves the corrosion resistance of the alloy. The corrosion inhibition efficiency of the modified magnesium alloy reaches 92.76%. After immersion in PBS for 14 days, the mass loss rate of AZ91D (40.59%) is almost 1.6 times that of Fe-LDH/AZ91D (25.16%), and the corrosion rate (4.14 mm/a) is about twice that of Fe-LDH/AZ91D (2.13 mm/a). The leaching solutions with different Fe-LDH/AZ91D volume fractions have good cell compatibility and can maintain the osteogenic activity of the cells, reaching the same level as the control group.
JING Shaohui,ZHOU Jixiang,ZHAO Dapeng, et al. Corrosion resistance, in-vitro degradation and osteogenic properties of AZ91D alloy modified by Mg-Fe-LDH coating[J]. Materials Science and Engineering of Powder Metallurgy, 2022, 27(5): 509-518.
[1] LÜ Y Y, ZHANG L F.Corrosion and protection of magnesium alloys[J]. Advanced Materials Research, 2015, 1120(7): 1078-1082. [2] JIANG X, GUO R G, JIANG S Q.Microstructure and corrosion resistance of Ce-V conversion coating on AZ31 magnesium alloy[J]. Applied Surface Science, 2015, 341(6): 166-714. [3] TANG H, HAN Y, WU T, et al.Synthesis and properties of hydroxyapatite-containing coating on AZ31 magnesium alloy by micro-arc oxidation[J]. Applied Surface Science, 2017, 400(1): 391-404. [4] GU X N, LI N, ZHOU W R, et al.Corrosion resistance and surface biocompatibility of a microarc oxidation coating on a Mg-Ca alloy[J]. Acta Biomaterialia, 2011, 7(4): 1880-1889. [5] LIN X, TAN L L, ZHANG Q, et al.The in vitro degradation process and biocompatibility of a ZK60 magnesium alloy with a forsterite-containing micro-arc oxidation coating[J]. Acta Biomaterialia, 2013, 9(10): 8631-8642. [6] GOLLWITZER H, HAENLE M, MITTELMEIER W, et al.A biocompatible sol-gel derived titania coating for medical implants with antibacterial modification by copper integration[J]. Amb Express, 2018, 8(1): 24. [7] KANG H, COSTA F C, SILVA R, et al.Mg-Al and Zn-Al layered double hydroxides promote dynamic expression of marker genes in osteogenic differentiation by modulating mitogen-activated protein kinases[J]. Advanced Healthcare Materials, 2017, 7(4):1700693. [8] HONGO T, TSUNASHIMA Y, YAMASAKI A.Synthesis of Ca-Al layered double hydroxide from concrete sludge and evaluation of its chromate removal ability[J]. Sustainable Materials Technologies, 2017, 12(1): 23-26. [9] ZHANG F, LIU Z G, ZENG R C, et al.Corrosion resistance of Mg-Al-LDH coating on magnesium alloy AZ31[J]. Surface Coatings Technology, 2014, 258(1): 1152-1158. [10] CHEN J, WU L, DING X X, et al.Effects of deformation processes on morphology, microstructure and corrosion resistance of LDHs films on magnesium alloy AZ31[J]. Journal of Materials Science and Technology, 2019, 64(2): 10-20. [11] DING C D, TAI Y, WANG D, et al.Superhydrophobic composite coating with active corrosion resistance for AZ31B magnesium alloy protection[J]. Chemical Engineering Journal, 2019, 357(3): 518-532. [12] HALLGREN C, REIMERS H, GOLD J, et al.The importance of surface texture for bone integration of screw shaped implants: An in vivo study of implants patterned by photolithography[J]. Journal of Biomedical Materials Research, 2015, 57(4): 485-496. [13] PARIENTE J, KIM B, ATALA A.In vitro biocompatibility assessment of naturally derived and synthetic biomaterials using normal human urothelial cells[J]. Journal of Biomedical Materials Research, 2015, 55(1): 33-39. [14] CHEN Y X, GAO Y S, GUO Y P, et al.Mg-Al layered double hydroxide/chitosan porous scaffolds loaded with Ta to promote bone regeneration[J]. Nanoscale, 2017, 9(20): 6765-6776. [15] SHI B F, SU Y B, ZHANG L L, et al.Nitrogen and phosphorus Co-doped carbon nanodots as a novel fluorescent probe for highly sensitive detection of Fe3+ in human serum and living cells[J]. ACS Applied Materials Interfaces, 2016, 8(17): 10717-10725. [16] ZENG H T, LACEFIELD W.The study of surface transformation of pulsed laser deposited hydroxyapatite coatings[J]. Journal of Biomedical Materials Research, 2015, 50(2): 239-247. [17] KANG Z X, LI W.Facile and fast fabrication of superhydrophobic surface on magnesium alloy by one-step electrodeposition method[J]. Journal of Industrial Engineering Chemistry, 2017, 50(10): 50-56. [18] BUCHANAN R, STANSBURY E.Electrochemical corrosion[J]. Handbook of Environmental Degradation of Materials, 2012, 3(2): 87-125. [19] ZHANG G H, WU L, TAN G, et al.Active corrosion protection by a smart coating based on a Mg-Al-layered double hydroxide on a cerium-modified plasma electrolytic oxidation coating on Mg alloy AZ31[J]. Corrosion Science, 2018, 139(7): 370-382. [20] MAN C, DONG C F, WANG L, et al.Long-term corrosion kinetics and mechanism of magnesium alloy AZ31 exposed to a dry tropical desert environment[J]. Corrosion Science, 2020, 163(2): 108274. [21] WANG L D, ZHANG K Y, WEN S, et al.Hydrothermal synthesis of corrosion resistant hydrotalcite conversion coating on AZ91D alloy[J]. Materials Letters, 2013, 106(1): 111-114. [22] WANG H X, YU B, WANG W W, et al.Improved corrosion resistance of AZ91D magnesium alloy by a zinc-yttrium coating[J]. Journal of Alloys and Compounds, 2014, 582(1): 457-460. [23] BAYATI M, MOSHFEGH A, GOLESTANI F.In situ growth of vanadia-titania nano/micro-porous layers with enhanced photocatalytic performance by micro-arc oxidation[J]. Electrochimica Acta, 2010, 55(9): 3093-3102. [24] GU X N, LI S S, LI X M, et al.Magnesium based degradable biomaterials: A review[J]. Frontiers of Materials Science, 2014, 8(3): 200-218. [25] WEIZBAUER A, KIEKE M, RAHIM M, et al.Magnesium-containing layered double hydroxides as orthopaedic implant coating materials—an in vitro and in vivo study[J]. Journal of Biomedical Materials Research, 2016, 104(3): 525-531. [26] SAJJAD J, SINGH R.In-vitro biodegradation and corrosion-assisted cracking of a coated magnesium alloy in modified-simulated body fluid[J]. Materials Science and Engineering C, 2017, 78(2): 278-287.