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粉末冶金材料科学与工程  2020, Vol. 25 Issue (4): 352-357    
  工艺技术 本期目录 | 过刊浏览 | 高级检索 |
TNZS基生物材料的体外组织相容性
赵倩
江苏大学 京江学院,镇江 212013
In vitro histocompatibility of TNZS-based biomaterials
ZHAO Qian
Jingjiang College, Jiangsu University, Zhenjiang 212013, China
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摘要 以Ti,Nb,Zr,Sn,Cu,Ag,Co等单质粉末为原料,采用高能球磨-模压成形-真空烧结工艺制备Ti-24Nb-4Zr-7.9Sn合金(简称TNZS合金),以及分别含有5%(质量分数)的Cu,Ag和Co的TNZS基合金(TNZS-5Cu,TNZS-5Ag 和TNZS-5Co合金)。在含10%胎牛血清的DMEM(Dulbecco’s modified eagle medium)培养基中接种SD大鼠成骨细胞,在合金表面进行细胞增殖、细胞贴附和细胞毒性实验。结果表明:在TNZS材料中分别添加5%的Cu,Ag和Co均能在一定程度上提高成骨细胞的增殖能力。在培育初期(24 h和72 h),TNZS-5Co合金表面最有利于促进细胞贴附;而在培育后期(120 h和168 h),TNZS-5Cu和TNZS-5Ag合金表面更有利于成骨细胞的贴附。TNZS-5Ag合金表面贴附的成骨细胞形貌和伸展度最好,其次是TNZS-5Co,而TNZS和TNZS-5Cu合金表面的细胞贴附能力相对较弱。4种TNZS基材料的细胞毒性等级均为2级,结合细胞形态进行综合评定,均符合生物医用植入体材料的细胞毒性要求。
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赵倩
关键词 TNZS合金生物材料粉末冶金组织性能    
Abstract:Ti, Nb, Zr, Sn, Cu, Ag and Co powders were used as the raw materials, Ti-24Nb-4Zr-7.9Sn(TNZS), TNZS-5Cu, TNZS-5Ag and TNZS-5Co (mass fraction, %) alloys were prepared by high-energy ball milling, cold pressing and vacuum sintering. SD rat osteoblasts were inoculated in dulbecco’s modified eagle medium (DMEM) with 10% fetal calf serum (FBS) and subcultured, and the cell proliferation, cell adhesion and cytotoxicity experiments were carried out. The results showed that addition of 5% Cu, Ag and Co to TNZS alloys could improve the proliferation of osteoblasts to a certain extent. The surface of TNZS-5Co alloy was the most favorable to promote cell adhesion at the early stage of culture (24 h and 72 h). At the later stage of culture (120 h and 168 h), TNZS-5Cu and TNZS-5Ag alloys were more favorable for the adhesion of osteoblasts. The morphology and elongation of osteoblasts attached to the surface of TNZS-5Ag were the best, followed by TNZS-5Co, while the cell adhesion ability of TNZS and TNZS-5Cu were relatively weak. The cytotoxicity grade of the four materials was level 2, which showed that all of them met the cytotoxicity requirements of the biomedical implant materials.
Key wordsTNZS alloy    biomedical materials    powder metallurgy    tissue    performance
收稿日期: 2020-04-20      出版日期: 2020-09-18
ZTFLH:  TG146+2  
通讯作者: 赵倩,硕士。电话:13921582276;E-mail: Qzhao666@163.com   
引用本文:   
赵倩. TNZS基生物材料的体外组织相容性[J]. 粉末冶金材料科学与工程, 2020, 25(4): 352-357.
ZHAO Qian. In vitro histocompatibility of TNZS-based biomaterials. Materials Science and Engineering of Powder Metallurgy, 2020, 25(4): 352-357.
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