间接3D打印制备Ti/HAp复合材料的结构与性能

doi:10.19976/j.cnki.43-1448/TF.2021072

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Abstract Rb-Hydroxyapatite (Rb-HAp) powders with different Rb content were prepared by ion-doped modification method, and then Ti/Rb-HAp composites were prepared by indirect 3D printing method. The morphology and phase composition of the composites were analyzed, the mechanical properties of the composites were determined, and the biological properties of the composites were studied by cell culture and cell proliferation and differentiation experiments in vitro. The results show that Ti/Rb-HAp composites have higher porosity, and the porous structure is favorable for the inward growth of new bone tissue and the transport of body fluid. The addition of Rb can improve the bending strength and compressive strength of Ti/HAp composites, and the compressive strength increases slightly with the increase of Rb content. Compared with the pure Ti group, Ti/Rb-HAp composites promote the proliferation and ALP activity of MG-63 cells, so the composite has good cytocompatibility. After immersion in simulated body fluid, a dense apatite layer formed on the surface of the composite, indicating that the Ti/HAp composites have excellent biological activity.

Key words： titanium/hydroxyapatite composites indirect 3D printing biocompatibility mechanical properties mineralization properties

Received: 24 August 2021 Published: 22 December 2021

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	LIU Yanjun
	LIU Ye
	TAN Yanni

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LIU Yanjun,LIU Ye,TAN Yanni. Structure and properties of Ti/HAp composites prepared by indirect 3D printing[J]. Materials Science and Engineering of Powder Metallurgy, 2021, 26(6): 515-524.

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http://pmbjb.csu.edu.cn/EN/10.19976/j.cnki.43-1448/TF.2021072 OR http://pmbjb.csu.edu.cn/EN/Y2021/V26/I6/515

[1] GEETHA M, SINGH A K, ASOKAMANI R, et al.Ti based biomaterials, the ultimate choice for orthopaedic implants-A review[J]. Progress in Materials Science, 2009, 54(3): 397-425.
[2] WANG C R, XIE Q Y, GUO Z, et al.A 3D printed porous titanium alloy rod with biogenic lamellar configuration for treatment of the early-stage femoral head osteonecrosis in sheep[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2020, 106(2): 453-460.
[3] MICHAEL D W, SCHUMACHER R, MAYER K,et al.Bone regeneration by the osteoconductivity of porous titanium implants manufactured by selective laser melting: a histological and micro computed tomography study in the rabbit[J]. Journal of Shoulder and Elbow Surgery, 2013, 19(23): 2645-2654.
[4] CACCIOTTI I, BIANCO A, LOMBARDI M, et al.Mg-substituted hydroxyapatite nanopowders: synthesis, thermal stability and sintering behaviour[J]. Journal of the European Ceramic Society, 2009, 29(14): 2969-2978.
[5] EDWIN N, SARANYA S, WILSON P.Strontium incorporated hydroxyapatite/hydrothermally reduced graphene oxide nanocomposite as a cytocompatible material[J]. Ceramics International, 2019, 45(5): 5475-5485.
[6] ŠUPOVÁ M.Substituted hydroxyapatites for biomedical applications: A review[J]. Ceramics International, 2015, 41(8): 9203-9231.
[7] CASARRUBIOS L, GOMEZ N, SANCHEZ S, et al.Silicon substituted hydroxyapatite/VEGF scaf-folds stimulate bone regeneration in osteoporotic sheep[J]. Acta Biomaterialia, 2020, 101(1): 544-553.
[8] GINESTE L, RAN Z, FRAYSSINET P, et al.Degradation of hydroxylapatite, fluorapatite, and fluorhydroxyapatite coatings of dental implants in dogs[J]. Journal of Biomedical Materials Research, 1999, 48(3): 224-234.
[9] LIU Y Q, CHUN D.Lithium-containing biomaterials stimulate bone marrow stromal cell-derived exosomal miR-130a secretion to promote angiogenesis[J]. Biomaterials, 2019, 192(2): 523-536.
[10] 谭彦妮,刘咏. 铷及含铷材料的性能与应用研究进展[J]. 中国有色金属学报, 2017, 27(2): 272-281.
TAN Yanni, LIU Yong.Research progress on properties and applications of rubidium and rubidium containing materials[J]. The Chinese Journal of Nonferrous Metals, 2017, 27(2): 272-281.
[11] OUYANG Z X, HUANG Q L, LIU B, et al.Rubidium chloride targets jnk/p38-mediated nf-κb activation to attenuate osteoclastogenesis and facilitate osteoblastogenesis[J]. Frontiers in Pharmacology, 2019, 10(7): 584-597.
[12] HAN C J, WANG Q, SONG B, et al.Microstructure and property evolutions of titanium/nano-hydroxyapatite composites in-situ prepared by selective laser melting[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2017, 71(5): 85-94.
[13] LI X, WANG T.Causes analysis on brittle fracture of pure titanium wires[J]. Physical and Chemical Tests-Physical Section, 2016, 52(1): 66-70.
[14] OMRAN A M, WOO K D, KANG D S, et al.Fabrication and evaluation of porous Ti-HA bio-nanomaterial by leaching process[J]. Arabian Journal of Chemistry, 2015, 8(3): 372-379.
[15] JANG Y E, LEE B N, KOH J T, et al.Cytotoxicity and physical properties of tricalcium silicate-based endodontic materials[J]. Restorative Dentistry & Endodontics, 2014, 39(2): 89-94.
[16] ZHANG J T, LIU W Z, SCHNITZLER V, et al.Calcium phosphate cements for bone substitution: Chemistry, handling and mechanical properties[J]. Acta Biomaterialia, 2014, 10(3): 1035-1049.
[17] OH I H, NOMURA N, MASAHASHI N, et al.Mechanical properties of porous titanium compacts prepared by powder sintering[J]. Scripta Materialia, 2003, 49(12): 1197-1202.
[18] JURCZYK K, NIESPODZIANA K, JURCZYK M U, et al.Synthesis and characterization of titanium-45S5 Bioglass nanocomposites[J]. Materials & Design, 2011, 32(5): 2554-2560.
[19] YANG X Y, LIU M, ZHAO Y, et al.Rational design and fabrication of a β-dicalcium silicate-based multifunctional cement with potential for root canal filling treatment[J]. Journal of Materials Chemistry B, 2014, 2(24): 3830-3838.
[20] GANDOLFI MG, CIAPETTI G, TADDEI P, et al.Apatite formation on bioactive calcium-silicate cements for dentistry affects surface topography and human marrow stromal cells proliferation[J]. Dental Materials, 2010, 26(10): 974-992.
[21] SEO M S, HWANG K G, LEE J, et al.The effect of mineral trioxide aggregate on odontogenic differentiation in dental pulp stem cells[J]. Journal of Endodontics, 2013, 39(2): 242-248.
[22] BOHNER M, LEMAITRE J.Can bioactivity be tested in vitro with SBF solution[J]. Biomaterials, 2009, 30(12): 2175-2179.
[23] LI P J, KANGASNIEMI I, GROOT K, et al.Bonelike hydroxyapatite induction by a gel-derived titania on a titanium substrate[J]. Journal of the American Ceramic Society, 1994, 77(5): 1307-1312.
[24] TAKADAMA H, KIM H M, KOKUBO T, et al.TEM-EDX study of mechanism of bonelike apatite formation on bioactive titanium metal in simulated body fluid[J]. Journal of Biomedical Materials Research, 2001, 57(3): 441-448.
[25] ROMERO F, SANCHEZ A M, ARAUJO N.Proteomic analysis of silica hybrid sol-gel coatings: A potential tool for predicting the biocompatibility of implants in vivo[J]. Biofouling. 2017, 33(8): 676-689.
[26] LI G Y, WANG P L, PAN W, et al.In vitro and in vivo study of additive manufactured porous Ti6Al4V scaffolds for repairing bone defects[J]. Scientific Reports, 2016, 6.
[27] CIVANTOS A, CRISTINA D, RAISA J P, et al.Designing bioactive porous titanium interfaces to balance mechanical properties and in vitro cells behavior towards increased osseointegration[J]. Surface and Coatings Technology, 2019, 368(25): 162-174.