为满足临床上对镁基金属植入物耐腐蚀和促成骨的要求,以AZ91D镁合金作为基体材料,采用水热法在其表面制备致密均匀的Mg-Fe-层状双氢氧化物(Fe-LDH)涂层,得到Fe-LDH/AZ91D样品。通过电化学和析氢实验探究涂层对镁基体耐腐蚀性和体外降解性能的影响,结合CCK-8及体外矿化实验研究Fe-LDH/AZ91D的生物相容性及成骨相关性能。结果表明：Fe-LDH涂层的存在为AZ91D与腐蚀液的直接接触建立了屏障,有效提升耐腐蚀性能,改性后的镁合金缓蚀效率达到92.76%;PBS中浸泡14天后,AZ91D的质量损失率(40.59%)几乎是Fe-LDH/AZ91D(25.16%)的1.6倍,腐蚀速率(4.14 mm/a)约为Fe-LDH/AZ91D(2.13 mm/a)的2倍;不同Fe-LDH/ AZ91D体积分数浸提液下细胞相容性良好,能较好地维持细胞的成骨活性,并达到与空白组样品同样的水平。
In order to meet the clinical requirements for corrosion resistance and osteogenesis of magnesium-based metal implants, the dense and uniform Mg-Fe-layered double hydroxide (Fe-LDH) coatings were prepared on the AZ91D Mg alloy matrix by hydrothermal method and the Fe-LDH/AZ91D samples were obtained. Electrochemical and hydrogen evolution experiments were performed to explore the effects of coatings on corrosion resistance and its in-vitro performance. Combining CCK-8 and in-vitro mineralization experiments, the biocompatibility and osteogenic properties of Fe-LDH/AZ91D were studied. The results show that the existence of the Fe-LDH coating establishes a barrier between AZ91D and the corrosive liquid and improves the corrosion resistance of the alloy. The corrosion inhibition efficiency of the modified magnesium alloy reaches 92.76%. After immersion in PBS for 14 days, the mass loss rate of AZ91D (40.59%) is almost 1.6 times that of Fe-LDH/AZ91D (25.16%), and the corrosion rate (4.14 mm/a) is about twice that of Fe-LDH/AZ91D (2.13 mm/a). The leaching solutions with different Fe-LDH/AZ91D volume fractions have good cell compatibility and can maintain the osteogenic activity of the cells, reaching the same level as the control group.
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